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Test ID PHSP Prenatal Hepatitis Evaluation, Serum


Necessary Information


Date of collection is required.



Specimen Required


Patient Preparation: For 24 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial within 24 hours.


Forms

If not ordering electronically, complete, print, and send 1 of the following:

-Gastroenterology and Hepatology Test Request (T728)

-Infectious Disease Serology Test Request (T916)

Secondary ID

5566

Useful For

Screening pregnant women for chronic hepatitis B and hepatitis C in primary care settings, with or without risk factors for hepatitis C

 

Determining the level of infectivity of chronic hepatitis B in pregnant women

This test is not useful for diagnosis of hepatitis B during the "window period" of acute hepatitis B virus infection (ie, after disappearance of hepatitis B surface antigen and prior to appearance of hepatitis B surface antibody).

 

This test should not be used as a screening test for hepatitis C in blood or human cells/tissue donors.

 

This test profile is not useful for detection or diagnosis of acute hepatitis C virus (HCV) in pregnancy, since HCV antibodies may not be detectable until after 2 months following exposure, and HCV RNA testing is not performed on specimens with negative HCV antibody screening test results.

Profile Information

Test ID Reporting Name Available Separately Always Performed
HBAGP HBs Antigen Prenatal, S Yes Yes
HCVSP HCV Ab Scrn Prenatal, S Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
EAG Hepatitis Be Ag, S Yes No
HEAB HBe Antibody, S Yes No
HBNTP HBs Ag Confirmation Prenatal, S No No
HCVRP HCV RNA Detect/Quant Prenatal, S Yes No

Testing Algorithm

If the result for hepatitis B surface antigen (HBsAg) prenatal is reactive, then HBsAg confirmation prenatal testing will be performed at an additional charge. If the HBsAg confirmation is positive, then HBe Ag and HBe antibody testing will be performed at an additional charge.

 

If the hepatitis C virus (HCV) antibody screen is reactive, then HCV RNA testing by reverse transcriptase-polymerase chain reaction will be performed at an additional charge.

 

For more information see Hepatitis B: Testing Algorithm for Screening, Diagnosis, and Management.

Method Name

Chemiluminescence Immunoassay (CIA)

Reporting Name

Prenatal Hepatitis Evaluation

Specimen Type

Serum SST

Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Frozen (preferred) 28 days
  Refrigerated  7 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

HEPATITIS B SURFACE ANTIGEN

Negative

 

HEPATITIS C ANTIBODY

Negative

 

See Viral Hepatitis Serologic Profiles

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

87340

86803

G0472 (if appropriate for government payers)

87522 (if appropriate)

86707 (if appropriate)

87341 (if appropriate)

87350 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PHSP Prenatal Hepatitis Evaluation 101653-4

 

Result ID Test Result Name Result LOINC Value
HBSAP HBs Antigen Prenatal, S 5196-1
HCVA6 HCV Ab Prenatal, S 40726-2